They complained of more frequent and intense joint pain (40% versus 22% at least once a week, 64% versus 38% moderate to intense pain), stiffness and swelling during the same period.
The proband presented normal development and growth and reported to be healthy until the age of 20 years, when she started to complain of frequent abdominal and joint pain.
Both patients with attenuated disease (cognitively intact) and those with severe disease (cognitively impaired) experience many somatic signs and symptoms that can reduce quality of life, including hepatosplenomegaly, impaired respiratory function, sleep apnea, frequent infections, and joint pain [ 17, 27, 37].
Signs of a vitamin C deficiency, also known as scurvy, may include bruising easily, slow-healing wounds, frequent infections and joint pain and swelling.
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(Carol)During the interview, six participants described symptoms that could be interpreted as being severe, for example, frequent spells of troubling joint pain and difficulty in using the affected joint(s).
Knee osteoarthritis is one of the most frequent joint disorders, and its major symptoms are pain and physical disability.
In older people, the most frequent cause of pain and disability is joint pain.
Joint pain is the most frequent symptom in patients with RA and generally decreases their functional status and quality of life, as it is strongly associated with physical disability, decreased mobility, depression, sleep disturbances and increased health-care costs [ 4- 7].
Headache was the most frequent (75.9%) symptom, and lethargy and muscle and joint pain were also reported by >50% of patients with dengue; however, these symptoms were just as frequent in patients without dengue.
