Sentence examples for frequent human tumours from inspiring English sources

However, MHC class II positive tumours only represent a minor fraction of the most frequent human tumours.

Given that non-melanoma skin cancers such as basal cell carcinoma and squamous cell carcinoma are the most frequent human tumours, it is important to understand the basic molecular mechanisms and the contribution of epidermal SCs to skin cancerogenesis (Boehnke et al, 2012).

Gliomas are the most frequent human primary brain tumours.

In this respect, it is noteworthy that the DUSP16 gene is located on chromosome 12p, an area of frequent chromosomal loss in human tumours.

This review will summarise our current knowledge of each member of the RASSF family and in particular what role they play in tumourigenesis, with a special focus on RASSF1A, whose promoter methylation is one of the most frequent alterations found in human tumours.

The p53 tumour suppressor plays a major role in cancer, as evidenced by frequent TP53 gene mutations in human tumours [ 1] and by the high incidence of cancer in Li-Fraumeni individuals carrying germline mutations in the TP53 gene [ 2].

Given these puzzling findings in human samples, the following key questions with respect to human Hippo signalling remain unanswered: To what extent and how frequent is Hippo signalling deregulated in human tumours?

As the initial immunohistochemical analysis has shown a frequent loss of ASS expression in SCLC human tumours, we have assessed the expression status of ASS in a panel of SCLC cell lines.

Increased ligand-induced EGFR activation is a frequent driving force in carcinoma progression, and in many human tumours, excessive shedding of one or more EGFR-ligands appears to be a key contributing factor [10], [25].

This observation, and the frequent appearance of resistance to more than one inhibitory cytokine in human tumours [ 13] emphasize the importance of the cell cycle effectors of growth arrest induced by TGF-β as targets for inactivation in cancer.

Adjuvant use of chemotherapy has established efficacy in several solid human tumours – breast, colon and lung cancers being among the most frequent.