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Exact(11)
The haplotypes may represent the ARQ and ARR haplotypes, which are the most frequent haplotypes in UK Scottish Blackface sheep, and which were shown to be linked to lamb mortality in the study of Sawalha et al. [10].
The three most frequent haplotypes in patients were the fbAt, FBaT, and fbAT.
There were four frequent haplotypes in Spaniards (ACCG, ATCA, GCGG, and GTGA).
In this context, the most frequent haplotypes in patients and controls were ACCAG and ACCGA.
A similar pattern was observed for the two most frequent haplotypes in the MC1R gene.
The three most frequent haplotypes in patients were the fbAt, FBaT, and fbAT, while this ranking in the control group was as follows: FbaT, fbaT, and FBAt.
Similar(49)
In addition, the extended homozygous stretch composed of the most frequent haplotype in the CEU population implies the existence of a long-range haplotype [26] in this region.
The deletion/deletion (DD) haplotype was the most frequent haplotype in both case and control populations, with a significantly higher frequency in the cases than controls (p = 0.032).
It should be noted, however, that there is a match between G9 and R2 (Table 2) who shares a frequent haplotype in haplogroup T2.
Two most frequent haplotypes of VDR, FbaT and FBAT and a relatively less frequent haplotype in patients fbaT do not show any significant difference between patients and controls when studied by themselves.
Statistics used in our method are haplotype homozygosity (HH), the probability that two haplotypes sampled at random from the population are same, and most frequent haplotype homozygosity (MHH), the probability that both the two haplotypes sampled are the most frequent haplotype in the population.
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