CxSCCs more frequently showed loss at 17p, while HNSCCs were characterised by frequent gains at chromosome 8q, harbouring the oncogene c-Myc [ 36].
Six chromosomal regions showed frequent gains of copy number (Table 1; Fig. 1).
Other frequent gains were observed on 20q (47%) and 12p (39%).
Luminal cell lines were characterized by more frequent gains on 1q, 8q, 11q, 12q, 14q, 17q and 20q, and losses on 8p, 9p, 11q, 13q, and 18p.
Since there is no clear consensus on what constitutes a "high-level" amplification, we report regions with frequent gains at log2 ratios of >0.6 (in 40 or more samples,10%+), >0.8 (5%+) and >1 (2.5%+).
Indeed, the history of these sequences is thought to be dominated by numerous events of loss [16] or due to frequent gains after a lateral transfer from a fungal donor [17].
Indeed, only chromosome 8q harbours frequent gains, involving many genes across the whole region.
In fact, Natrajan et al. (2006) detected frequent gains on chromosomes 8 and 12.
In SIOLs, frequent gains (≥50%) were detected on 13 chromosomal lesions (Fig. 2a).
On the other hand, HNSCCs showed frequent gains at chromosome 8q and losses at 11q.
The mucinous carcinomas (n = 3 with imbalances) showed frequent gains of 7q22-31, 7q34, and 8q23 (67%).
