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Despite the good results for trivial and systematic mentions of chemicals, examining some of the frequent false negative cases not detected by many of the participating teams showed that there were also some common difficulties.
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When used daily, TCDs have been 60-70% sensitive for delayed cerebral ischemia with limited predictive value; they also exhibit frequent false negatives or false positives [ 44].
In traditional HTS, compounds are tested at a single concentration and the results are therefore burdened by frequent false negatives or positives.
The diagnostic accuracy of the ABCDE criteria has been verified in clinical practice; however, it only provides qualitative guidelines for melanoma identification and yields high rates of false positives and frequent false negatives.
Gallium imaging is not an accurate technique for detecting sites of involvement at diagnosis, with frequent false-negative results compared to CT, and also false-positive para-hilar uptake [ 3].
We can nevertheless reasonably assume that "false positives" (something recorded but not done) are far less frequent than "false negatives" (something done but not recorded) even if this has not been definitively established.
Despite its widespread use for monitoring therapeutic response in OvCa patients, CA125 is a poor marker for early diagnosis due to frequent false positive and false negative results.
The most frequent reason for false negative cases was related to the number of cases not attended in hospital settings.
Interobserver agreement on chest imaging is poor, leading to frequent false positives and false negatives [ 12, 13].
However, chest radiographs have high interobserver variability, leading to frequent false positives and negatives [ 12, 13].
High ApoA1 was the most frequent cause (0.21%) of false negative risk and was associated with the tertiary care reference center.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com