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Accumulating data have revealed the frequent existence of mosaic HBV genomes, which are generally considered to be the result of recombination between two different genotype strains.
This and the frequent existence of asexual strains within sexual species, makes the separation between sexual and asexual species imprecise.
A major limitation in the interpretation of polymyxin-induced nephrotoxicity and neurotoxicity in the intensive care unit setting, however, is the frequent existence of multiple organ failure, septic shock, and mechanical ventilation support.
However, the main concern with respect to the use of metformin in the older adult with diabetes relates to the frequent existence of impaired renal function that should be regularly monitored in all patients on the drug [ 14, 15, 139].
From the GP's perspective, the result could be attributed to a lack of knowledge about the frequent existence of ambivalence, a need for communicative education in handling of ambivalence or intentionally moving away from such issues in the consultation, for instance due to lack of time.
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It is possible that the frequent occurrence of IDC in patients followed for LCIS may be explained by the frequent co-existence of LCIS and DCIS in these patients, with the DCIS acting as the precursor to the IDC.
Treatment of patients with chronic migraine remains challenging in daily clinical practice due to several factors: variable tolerability of the currently available medical treatments, frequent co-existence of medication overuse and lack of disease specific treatment strategies.
The frequent co-existence of MPD, SVT and JAK2V617F mutation has directed us towards genetic analysis in our patient.
The very frequent co-existence of these two clinical situations (smoking and adiposity) needs to be better understood [ 9].
Moreover, thyroid disease in older patients requires special attention because of the increased gravity caused by the frequent co-existence of other pathologies or the greater risk of pharmacological interferences and a lower metabolism of the drugs.
The ability of oligomeric tau derived from PSP to seed different types of tau may underlie the frequent co-existence of other neurodegenerative tauopathies in patients with PSP [ 43].
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