Target diseases included obesity and its 15 most frequent comorbidities exhibited by patients, while the target labels corresponded to expert judgments based on textual evidence and intuition (separately).
Cells with frequent flashes exhibited transient GCaMP3 increases of mixed duration, but a few cells showed recurring transient increases that lasted over an extended period of time (categorized as 'frequent extended'), often with varying intensities within the elevated GCaMP3 signal.
For those frequent cases exhibiting additional non-CTLP CNA events, their possible contribution to oncogenesis has to be considered when modeling the role of chromothripsis-like events in cancer development.
Consistent with this notion, cognitive impairment can be found in up to 75% of HF patients with frequent deficits exhibited in cognitive domains shown to be important contributors to driving ability in other medical populations (e.g., Alzheimer's disease, mild cognitive impairment), including global cognitive function, attention, executive function, and psychomotor speed [ 9- 16].
Lowengart et al. (1987) reported a statistically significant association between childhood leukemia (all types) and maternal use of paint during pregnancy (OR = 1.8, p = 0.03) based on 42 discordant case control pairs, but attributed their results to chance because frequent users exhibited a lower and nonsignificant OR ORR = 1.3, p = 0.30, based on seven discordant pairs).
However, the use of a cable requires frequent maintenance and exhibits lower reliability than a gear-driven mechanism.
We investigated this duality in pancreatic ductal adenocarcinoma (PDA), which, with other gastrointestinal cancers, exhibits frequent inactivation of the TGF-β mediator Smad4.
We show that monomeric XPD unwinds duplex DNA in 1-bp steps, yet exhibits frequent backsteps and undergoes conformational transitions manifested in 5-bp backward and forward steps.
DPC4 (Smad4), a tumor suppressor gene, exhibits frequent mutations accompanied by LOH in approximately 20%% of pancreatic cancers [ 19], but no mutations have been reported in gastric cancers [ 20].
Unlike Her2-positive or ER-positive breast cancers that have relatively limited loss of RB, TNBC exhibits frequent loss of RB as determined by histological analysis [ 38, 39].
