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This result may be widely helpful, thanks to the frequent emergence of a HNFDE with non-uniform delay in various fields.
As pointed out by Romick-Rosendale and co-workers in a recent review [11], the frequent emergence of SCC in FA must be seen in the context of defective DNA repair compromising genomic integrity.
Clonal analyses of iPSCs expressing HSVtk revealed frequent emergence of GCV resistance which, at least in some cases, could be attributed to preexisting inactivating mutations in the HSVtk coding sequence, selected for upon GCV treatment.
However, we have observed papillae when W303 kan+ URA3 CEN strains are transferred to 5-FOA, implying relatively frequent emergence of suppressors.
The frequent emergence of drug resistance phenomena to structurally and functionally unrelated anticancer drugs known as multidrug resistance (MDR) continues to be a major impediment to curative cancer chemotherapy [1], [2], [3], [4], [5], [6].
However, the frequent emergence of inherent and acquired antifolate resistance in solid tumors calls for the development of novel therapeutic strategies to overcome this chemoresistance.
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Emergence of VDPVs from the Sabin OPV2 strain has been much more frequent than emergence of VDPVs from OPV1 and OPV3.
The effect of frequent H5N1 emergence from a wildfowl reservoir imposes a negligible to minor additional increase in selection for host resistance (Figure 4).
Probably, the single most interesting results is the frequent, rapid emergence of excessive complexity, with subsequent simplification as the systems is optimized by selection.
Calling (total number of call bouts recorded at the study site) is more frequent following pup emergence, and adults may decrease their responsiveness accordingly (Loughry and McDonough 1989).
Genes are lost with probability v, an event that is far more frequent than the emergence of new gene types u, and h is the mean number of genes gained per genome by HGT.
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Justyna Jupowicz-Kozak
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