Sentence examples for frequent dosing regimen from inspiring English sources
A frequent dosing regimen is often necessary because of their short plasma half-lives, causing poor patient compliance (e.g. pain, abscess, etc)., side effects owing to typical peak-valley plasma concentration time profiles, and increased costs.
While a less frequent dosing regimen generally increases adherence (Saini et al. 2009; Claxton et al. 2001), it may not improve outcomes (Comté et al. 2007; Richter et al. 2003; Vrijens et al. 2014; Vrijens and Heidbuchel 2015; Harden 2017; Bialer 2007).
A less frequent dosing regimen would not lead to a sustained PASI-75 response.
Furthermore, owing to the short half-life of protein in vivo, maintaining therapeutically effective serum levels needs a frequent dosing regimen and high doses of expensive purified recombinant proteins.
Understanding these properties would be critical to exploiting the full therapeutic potential of this pathway for example, to develop a non-redox 5LO inhibitor with less frequent dosing regimen than zileuton (e.g., once daily).
Treatment cost savings associated with panitumumab were related to a low rate of severe infusion reaction versus cetuximab, reduced hospital costs associated with a less frequent dosing regimen and patients' weight savings across a normally distributed patient population.
"Patients have been found to be better at taking the weekly rather than the daily dosed oral bisphosphonate, suggesting that less frequent dosing regimens may further improve adherence and, therefore, long-term clinical outcomes," she said.
Also reviewed are results of "bridging" studies designed to demonstrate the comparable efficacy of less frequent dosing regimens to increase bone mineral density and to reduce bone turnover.
Simpler, less frequent dosing regimens result in better compliance [ 37].
Less frequent dosing regimens may also be associated with smoother control of Hb concentrations [ 14].
Our results are consistent with a priori expectations that patients prefer higher efficacy, lower costs and less frequent dosing regimens.
