Cost-conscious physicians, however, will also be forced to consider the relative merits of more expensive, less frequent dosing with VTE versus the more frequently dosed, lower cost alternative, off-label bevacizumab.
This dosage form presents the clinical advantage of less frequent dosing, with increased quality of life for patients.
Frequent dosing, with little or no short-lived effects, results in ongoing risks to staff and patient.
Taken together, these results suggest that in all the tissues tested, maximum GL-3 reduction can be obtained using a combination of ERT plus SRT, and that within this context, more frequent dosing with enzyme appears to be more effective.
13 In the USA, ranibizumab once monthly is recommended; however, patients may receive three or four monthly doses followed by less frequent dosing with regular assessments.
The pharmacokinetic parameters of phenylbutazone also suggest a much shorter duration of effect when compared to meloxicam while requiring more frequent dosing with extended duration dosing regimens.
In the USA, ranibizumab once monthly is recommended; however, patients may receive three or four monthly doses followed by less frequent dosing with regular assessments.
The paper also reviews the clinical evidence for risedronate, demonstrating the viability of less frequent dosing, with its potential benefits for patient convenience and adherence to therapy.
In contrast to these findings, a trial in Malawi recently reported clear benefit from more frequent dosing with SP-IPTp and azithromycin.
However poor adherence in the ritonavir group when measures are capped indicates that there is not always compliance with frequent dosing with an unpalatable drug ultimately impacting negatively on adherence.
