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(C) Top 20 most frequent domain function combinations (counting >50).
Analysis of phylogenetic profiles, genomic context, domain architectures and sequence identity reveal that sensory modules of chemoreceptors that detect environmental cues are the subject of frequent domain birth and death events and have accelerated rates of sequence evolution.
Where annotation is more frequent, domain fusion methods may provide a greater increase in coverage by identifying associations for more proteins.
The commonality between these studies is that family was consistently nominated as the most frequent domain.
Two of the most frequent domain mutations, which show resistance to Imatinib (MutY253F and E255K), responded to treatment with AZD0530.
The second most frequent domain, Fibronectin type III domain (fn3), belongs to the Ig-like fold superfamily.
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The first step in this project was to determine the most frequent domain-specific predicates represented in the data.
Protein kinase, cytochrome P450, and the RNA recognition motif were the most frequent domains.
The most frequent domains were PF00527 and PF00098, which were conserved among five species from Papillomaviridae and Retroviridae family, respectively.
Ortho script was also able to compute the most representative Pfam IDs of each species (exclusive domains relative to other species and most frequent domains).
The 215 RGAs contained different types of conserved domains; LRRNT/LRR, NB-ARC and PKc/PKc_like were the three most frequent domains in RGAs (Table 1).
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