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In northern Germany the dukes of Brunswick dissipated their strength by frequent divisions of their territory among heirs.
Thus, human ST-HSCs, similar to mouse, have lower repopulation capacity, more frequent divisions, and a distinct transcriptional profile compared to LT-HSCs.
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Phlox paniculata is "trouble free" in being difficult to kill, but that same robustness means it needs frequent division.
The demarcation of the ABC transporter genes (blpA) and transport accessory protein gene (blpB) was highly variable even within Categories, and the frequent division of blpA into multiple ORFs was consistent with findings from previous studies [ 21, 22].
Another characteristic feature for both mutants was a disrupted cell division pattern with frequent periclinal divisions of outer layer cells.
These data are compatible with a model in which CD44+CD24low+ undergo largely asymmetric division, with a modest CD44+CD24low+ population increase due to less frequent symmetric divisions (Fig 2D and E).
Tumors are characterized by frequent mitotic divisions and chromosome instability.
A high turnover rate would allow quick restitution of the lost tissue due to damage; but on the other hand, high turnover rate would require the presence of more active stem cells around and more frequent cell divisions, increasing the susceptibility to genome duplication-induced mutations and the risk of carcinogenic transformation of the intestinal tissue.
At the tip of the limb bud, the AER-signal concentration is high (see Fig. 6 a2)), which leads to frequent cell divisions.
This major conceptual difference is likely because highly dividing microorganisms face extensive dilution of their enzyme concentrations through the frequent cell divisions, while cells of higher organisms relatively infrequently divide in the short time scales of environmental changes.
In contrast, the MOSJ-Dkk1 cells not only survived this challenge, forming and maintaining a stable confluent monolayer, but also continued to undergo frequent cell divisions that could be observed above the plane of the monolayer.
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