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Pancreatic ductal adenocarcinoma (PDAC) is the most frequent pancreatic cancer type and is characterized by a dismal prognosis due to late diagnosis, local tumor invasion, frequent distant metastases and poor sensitivity to current therapy.
Loss of RKIP predicts features of EMT and correlates with frequent distant metastasis.
The lung, bone and soft tissues were the most frequent distant localizations.
RKIP loss in the tumour centre independently predicted more frequent distant metastatic disease (P=0.0307).
The most frequent distant sites of disease were lymph nodes, peritoneum and lung.
Reports have shown that despite adequate local control, there were patients who still suffered frequent distant metastasis.
Similar(50)
Expression of Claudin-4, CAIX and GLUT-1 was significantly more frequent in distant metastases compared to their primary tumors (negative to positive conversion).
Liver is the most frequent site of distant metastases.
It plays a critical role in metastatic processes as shown for breast [24], [25], ovarian [26] and prostate cancer [27] and CXCL12 is highly expressed in organs which are frequent sites of distant metastases like lung, liver and lymph nodes [28].
Interestingly, identical haplotypes were also frequent in geographically distant regions.
The liver was the most frequent site of distant metastasis (20 patients).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com