Sentence examples for frequent discontinuation from inspiring English sources

Classic DMARDs such as methotrexate should be closely monitored as they proved most hepatotoxic and led to frequent discontinuation.

Requirements for patients in AOTs were: having frequent and/or long admissions poor or no improvement in psychopathology and illness management, frequent discontinuation of treatment, or relapse.

In addition, antidepressant use is often associated with a number of adverse events which lead to frequent discontinuation of such treatment [ 8].

Considering frequent discontinuation of CsA due to CsA-related renal insufficiency [8] and the use of CsA in transplantation patients for controlling organ rejection [24], we prematurely adjusted the dose of CsA, predicated on the blood trough concentration of CsA and elevated serum creatinine before and during treatment.

2 5 Increasing charges for prescription medicines and/or cost barriers to collecting prescription medication have been associated with lower rates of use, 6 9 lower prescription medicine compliance, 6 more frequent discontinuation 6 and increased use of health services among some groups.

The most frequent discontinuations were with carbamazepine (27.3%), followed by gabapentin(17.4%, p < 0.01) and then by lamotrigine (10%, p < 0.00003).

Outside of controlled trials, more frequent discontinuations of treatment, delays in the irradiation protocol and reductions in radiation doses occur, which indicate that certain results obtained in trials can only be partially transferred to the clinical practice.

The overall pooled data for prasugrel and ticagrelor showed that prasugrel and ticagrelor were superior to clopidogrel in reducing the major clinical end points, without any significant difference in stroke or major bleeding, despite more frequent drug discontinuation.

Docetaxel was generally well tolerated; the weekly regimen showed less febrile neutropenia than the 3-weekly regimen but a higher rate of fatigue, resulting in frequent treatment discontinuation [ 39].

Of note, the overall frequency of various side effects in the combined POWER analysis was higher in the CPI-treated patients, in spite of the lower levels of overall drug exposure in this group (where higher rates of treatment failure lead to more frequent treatment discontinuation in the CPI group).

A recently published safety analysis of the XELOX NO16968 study (Schmoll et al, 2007) found more frequent treatment discontinuations with XELOX compared to the FU/LV Mayo and Roswell Park regimes; however a comparable number of patients completed 12 weeks of therapy (88 and 82%, respectively).