Spanish-language American countries have developed their own standards, differing mainly in phonology (in which they often agree with the southern Spanish dialects) and in vocabulary (in which loanwords from English are more frequent), but differentiation is comparatively slight, and some Americans still regard true Castilian as their model.
Colorectal cancers with CIMP-H showed more frequent poor differentiation than CIMP-0,L CRCs (P<0.001).
Because spontaneous regression is rare (frequent spontaneous differentiation of screening detected neuroblastoma of infancy is a notable exception), research on spontaneous regression in human cancer is difficult.
ccrcc4-tumors exhibited frequent sarcomatoid differentiation with a strong inflammatory, Th1-oriented but suppressive immune microenvironment, with high expression of PDCD1 (PD-1) and its ligands PD-L1 and PD-L2.
In particular, naive cells, CD4 and CD8 alike, are progressively depleted, possibly as a consequence of their frequent activation and differentiation into memory cells caused by chronic and high antigenic stimulation.
When Nm > 4, gene exchange is more frequent and genetic differentiation is much smaller [ 58, 59].
These markers were examined in tumours from an African population in which breast cancer is assumed to be more aggressive and also associated with frequent basal-like differentiation (Nalwoga et al, 2007).
Moderate differentiation and frequent gene flow were detected among all populations (FST = 0.0659, P = 0000, Nm = 3.5436).
Availability of frequent measurements permitted accurate differentiation of effects for different averaging periods.
Algarobia DC., due largely to the phenotypic variation within species and the low genetic differentiation and frequent hybridization among species (Hunziker et al., 1986).
