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Administration of glucose should therefore be individually titrated according to frequent determinations of glycaemia, rather than by following standard protocols.
For fine-tuning, frequent determinations of hematocrit were carried out to reach a target hematocrit level of 24±2%24±2%
Women with diabetic nephropathy were followed with frequent determinations of UAE, whereas in women with normoalbuminuria or microalbuminuria, further analysis of UAE was only performed systematically when dipstick analysis was ≥1+ during pregnancy.
Meticulous supportive care, including close monitoring of fluid intake and output, frequent determinations of electrolytes, and appropriate management to maintain balance of fluids and electrolytes, is required when renal adverse effects of polymyxin use are detected.
To counteract this problem a potential solution may be to conduct repeated and relatively frequent determinations of XIAP mRNA levels during therapy where a consistent trend may emerge that can then be more confidently distinguished from background variability.
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A recent editorial has highlighted that frequent determination of troponin in the ICU patient can lead to 'troponinitis'troponinitis
Frequent CK determinations were performed according to a schedule that called for 4 to 8 measurements in the first 96 hours to calculate the area under the CK curves.
Immunosuppresive medications were routinely evaluated by frequent blood level determinations and adjusted for clinical events without consideration of statin use.
Finally, frequent blood glucose determinations impose increased nursing workload, and acceptance of the protocol by nurses is very important for successful implementation.
Second, it is preferable to use a dynamic scale protocol with continuous insulin infusion combined with frequent blood glucose determinations (hourly to every four hours) and to use the last two blood glucose values to determine the insulin infusion rate.
Tight glycaemic control in critically ill patients can best be achieved using a protocol with continuous insulin infusion combined with frequent blood glucose determinations and the use of the last two blood glucose values to determine the insulin infusion rate.
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