In our study, there were no technical problems in detecting mutations; the frequent detection of SNPs demonstrates the high sensitivity of our procedure.
The scarcity of ZYMV reservoirs contrasts with the frequent detection of WMV in the same samples.
Because of the frequent detection of carcinoma in surgical specimens after hysterectomy for endometrial complex atypical hyperplasia (CAH), it has been suggested that patients with a preoperative diagnosis of CAH be referred to gynecologic oncology for potential lymphadenectomy.
When grown in Vero cells, these bacteria appeared more evenly distributed (Fig. 4A), a point consistent with the frequent detection of actin comets (Fig. 4B).
The frequent detection of recombination events in all patient groups described makes the capability of HCV to produce recombinant forms not only relatively frequent but also effective and, depending on the recombinant strains produced, it might be selectively advantageous.
The frequent detection of HRV-C mono-infection in a substantial proportion of subjects presenting with LRTIs and URTIs (Fig. 4) is concordant with recent PCR-based studies [13] [17], [29], [33], [34] that demonstrate a numerically significant role for HRV-C and other rhinovirus species in severe respiratory disease requiring hospitalisation in children and exacerbation of asthma.
These species C rhinoviruses (HRV-Cs) have been shown to be highly prevalent, with initial studies demonstrating frequent detection of this species in association with bronchiolitis and other lower respiratory tract disease [9], [12] [14], in asthma exacerbations [9], [14] [16] and otitis media [17].
Despite frequent detection of Proteobacteria-like nifH genes in PCR amplicons as well as in real-time PCR based studies from open oceans [41] [44], these putative diazotrophs have received limited attention, perhaps because open ocean waters that are well-oxygenated and poor in energy sources would appear to be unfavourable for expression of the nitrogenase genes [45].
Therefore, our findings do not support the hypothesis of a role of EBV, CMV, or HHV-6 in the pathogenesis of LCH, and indicate that the frequent detection of Epstein-barr virus (EBV) in Langerhans cell histiocytosis is accounted for by the infection of bystander B lymphocytes in LCH granuloma.
Rare findings of HBV/E in the Americas suggest a relatively recent HBV/E expansion in the human population in Africa, because the high HBV/E prevalence in Africa coupled with the high volume of the Afro-American slave trade that took place between the 17th and the 19th century [8], [11], [12], [13] would have resulted in frequent detection of HBV/E infection in the Americas.
One study reported the frequent detection of anti-RPA autoantibodies in cancer patients [ 26].
