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One copy was the most frequent copy number, occurring in 44.3% of the controls and 41.9% of the RA patients.
The frequent copy number losses of 9p and 10q in our cohort of tumors directed our investigation into the loss of gene expression of key tumor suppressor genes found in these two regions.
Despite this complexity, published copy number profiles of ovarian cancers are highly comparable at a global level [3] and many studies have identified very similar regions of frequent copy number alteration.
Most frequent copy number gains were observed on chromosomes 8, 9q, 11q and 20.
These studies have identified regions of frequent copy number changes in breast cancer.
The frequent copy number changes, especially on chromosome 1q, 3q, 3p, and 5p, were consistent with previous reports [ 20, 21].
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It is this frequent copying of established designs that causes the architecture from this period, while opulent, also to be disciplined and almost reined in.
As shown in Figure 5, the stable and unstable clusters are characterized by infrequent and frequent copy-number losses/gains, respectively, reflecting different degrees of genetic instability.
Global hypomethylation of LINE-1 is associated with the progression of and poorer prognosis for MM, possibly due to frequent copy-number loss.
Basal-complex tumors had frequent copy-number losses on chromosome 5q, in line with previous studies showing loss of heterozygosity (LOH) and physical deletions of 5q in BRCA1 tumors [ 30, 32].
The clinical significance of AZFc deletions becomes evident when considering that they not only represent one of the most frequent copy-number variants in the human genome, but also that they can decisively impact male fertility (Vogt, 2004; Krausz and Degl'Innocenti, 2006; Noordam and Repping, 2006; Tyler-Smith, 2008).
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