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However, when study populations are comprised of individuals with frequent and variable pre-treatment elevations of liver enzymes, such as in clinical trials to treat chronic viral hepatitis or non-alcoholic steatohepatitis (NASH), population-based upper limits of normal do not apply.
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There is also evidence that fewer than 24 monthly injections of ranibizumab may be just as efficacious, and trials are underway evaluating less frequent dosing, and variable dosing regimens guided by visual acuity and optical coherence tomography findings [ 1, 5, 6].
These results indicate that prodrug 2 has the potential for safer, lower, less frequent, and less variable administration than ribavirin.
We restricted this study to the hospital setting because palliative care consultation in the outpatient context is comparatively newer, less frequent and highly variable in terms of reasons for referral [ 29, 30].
A descriptive analysis of some (more frequent) codes and variables was carried out with SPSS 14.0.
The flux meter measurements reveal that the subsurface hydrology in the vicinity of the mound is complex and variable with frequent changes from downward to upward flow ranging from − 161 to 273 cm/yr, and with temporal variations in the horizontal component of flow.
Limb salvage surgery was performed in six cases, with frequent mechanical and infectious complications and variable functional outcomes.
This analysis suggested that ongoing introgression is frequent between all three species and variable in extent between loci.
Simulations considering the constraints of farm work organisation showed that soil compaction was more frequent and sowing date more variable in the case of winter and spring peas than in the case of the new Hr pea genotype.
The applications with high and variable requirements necessitate frequent changes in their VMs [2] and dynamic management.
Compared with conventional arthroplasty, tumor endoprosthesis is less frequent, and the accompanying independent variables much more diverse.
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