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However, its half-life in the vitreous humor is very short, which means that it typically requires frequent administrations, thus reducing patient adherence and causing therapeutic failure.
On the other hand, the liposomal delivery has a number of other advantages showing good therapeutic responses at lower drug doses and less frequent administrations.
The large dose and frequent administrations of this compound suggest a relatively low specificity for ALS 1-0635 compound.
Studies with more toxic chemotherapies including frequent administrations (and more aggressive control arms) may show different results.
If frequent administrations of extra boluses of sedative or opioid were necessary, then continuous infusions were begun.
Due to its short half-life (approximately 15 20 min) after parenteral administration, frequent administrations are required to maintain its pharmacological effects [ 19].
Similar(45)
Some have a central line implanted to aid in the frequent administration of antibiotics.
But the move did draw praise from a frequent administration critic.
Frequent administration of ISDN has been shown to result in the early development of nitrate tolerance.
This approach has been termed 'dose density', which captures the concept of optimally frequent administration.
On the other hand, its short half-life necessitates its frequent administration in short time lapses.
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