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Some have a central line implanted to aid in the frequent administration of antibiotics.
Frequent administration of ISDN has been shown to result in the early development of nitrate tolerance.
Therefore, NLC of docetaxel in gel might reduce frequent administration of drug which was desired clinical application of this project.
Therefore, frequent administration of excessively high dose of a protein is required to observe its therapeutic effect in vivo.
Moreover, the frequent administration of the cocktail (ARVs are administered at least once a day) favors treatment interruption.
Moreover, the more frequent administration of the IFNb preparation, as performed here, seems better than the administration of IFNb-1a just once a week [20, 21].
Owing to frequent administration of a wide range of pharmaceutical products, various environmental waters have been found to be contaminated with pharmacologically active substances.
The clinical diagnosis is further hampered by the frequent administration of sedative or paralytic agents to the newborn patients in neonatal intensive care units.
It overcomes the deficiencies of currently approved ESA, including the frequent administration of temperature-sensitive recombinant protein and anti-EPO antibody-mediated pure red cell aplasia (PRCA).
The frequent administration of several drugs in relatively high doses is a main cause of patient incompliance and a hurdle toward the fulfillment of the pharmacotherapy.
Consequently, frequent administration of an excessively high dose of a protein is required to obtain its desired therapeutic effect in vivo, leading to a disturbance in the homeostasis and unexpected side effects.
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