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In order to get new insights on the mechanism of expression of these genes we intended to define the correlation between CT7 and CT10 expression and the presence of activating KIT mutations; this is based on the frequent activation of the KIT gene in MM and the finding that an activated KIT may allow MAGE gene expression in mast cell leukemia [ 27].
Due to frequent activation of EZH2 in lymphoma, these new targeted therapies hold exciting promise in the clinic.
Moreover, a droop curve with a suitable dead band can prevent the droop controller from frequent activation in response to small frequency fluctuations [4].
In particular, frequent activation of OCGT with high marginal cost to manage unexpected sudden wind drops lead to extreme high imbalance prices.
Endometrial adenocarcinoma has been proposed, due to frequent activation of the PI3K/AKT pathway, as a candidate neoplasm for treatment with mTOR inhibitors.
The wet winter of 2013 with elevated shallow groundwater levels led to more frequent activation of sub-surface pathways and tile drain flow.
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Furthermore, the present study indicates that in activation studies during anesthesia, a relatively high degree of smoothing (e.g., filter kernel equivalent to 2- to 3-fold the FWHM) results into considerably less frequent "activations" in extra-auditory regions (Table 4, Fig. 2).
Taken together, the more frequent activations to conditioned aversive stimuli compared to primary punishers is probably explained by the nature of the two response components.
Dopamine neurons show frequent activations following conditioned aversive stimuli presented in random alternation with reward predicting stimuli; the activations disappear largely when different sensory modalities are used (65% vs. 11% of neurons [ 33]), suggesting coding of non-aversive stimulus components.
However, the more frequent activations to the conditioned stimuli compared to the more aversive primary air puff (37% vs. 11% [ 46]) suggests an inverse relationship to the aversiveness of the stimuli and possibly non-aversive response components.
Inhibitors of PI3K/Akt signaling are being actively developed for tumor therapy owing to the frequent mutational activation of the PI3K-Akt-mTORC1 pathway in many cancers, including glioblastomas (GBMs).
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