Sentence examples for frequent activating from inspiring English sources

Cappellen, D. et al. Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas.

In the current study, we compared allele-specific qPCR assays for the most frequent activating mutations in EGFR, KRAS, BRAF and PIK3CA in tumor-positive fine needle cytological aspirates against histological material of primary tumors.

Since the discovery of frequent activating BRAF mutations in melanoma (Davies et al, 2002), myriads of papers have published reporting the detection of BRAF mutations in melanoma (reviewed in Hocker and Tsao, 2007).

Less frequent activating BRAF mutations (e.g. V600K, V600D, V600M) have been observed in malignant melanoma [ 17- 20] and other non-CNS tumors [ 4, 21] but only rarely have been identified in primary CNS tumors [ 6].

First, we focused on cancer types known to have frequent activating mutations in KRAS or EGFR: colorectal adenocarcinoma (COAD) and glioblastoma multiforme (GBM), respectively (Cancer Genome Atlas Research Network, 2008; Cancer Genome Atlas Network, 2012).

Five (cases 3, 4, 5, 12 and 13) out of six NSCLC patients that are negative for EGFR-T790M mutation harbored "compound mutations" (a rare EGFR mutation in combination with a more frequent activating mutation).

Urothelial carcinoma (UC) of the bladder, the most common type of bladder cancer, is characterized by several gene mutations of which the most frequent is activating mutations in the FGFR3 receptor protein.

Altogether, these results suggest that PIK3CA mutations are not a frequent AKT activating mechanism in lymphoid neoplasm.

In addition, high sensibility mutation detection methods were also developed to perform a mutational screening study for the most frequent EGFR activating mutations.

CRC is unusual compared to other cancers in that loss of function mutations in APC are much more frequent than activating mutations in β-catenin (i.e. in exon 3), ∼75% compared to ∼5%, respectively (TCGA, 2012).

It requires frequent precharging and activating new rows, and results in extra latencies for reading and writing pixel data in memory devices.