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The frequency score represents the fraction of SNV at the middle nucleotide in a heptamer that varies with an allelic frequency >0.0001.
ICCs for the frequency-weighted scores (item severity score x item frequency score) ranged from 0.69 to 0.98 for the seven symptom categories (ps < 0.001).
These two values were then combined in unified score, called intensity weighted frequency score (IwF).
Hence, an overall average design frequency score was calculated for each of the participants based on the designs they produced.
The first combination has the molecular function and the frequency score filter and the second combination has the cellular function filter and the frequency score filter.
The cellular function filter is similar to the MnM frequency score filter in performance.
The first combination filter employs the molecular function and the frequency score filters.
To begin with we have plotted the ROC curve for the frequency score filter.
As a result, fifteen threshold parameters were formed for this combination of cellular function and frequency score filters.
The second combination filter employs the cellular function filter and frequency score filter in the same way.
Table 3 shows a comparison of the new filters with the frequency score filter on various aspects.
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