Sentence examples for frequency of toxicity from inspiring English sources

However, due to the high frequency of toxicity, general treatment intensification seems unacceptable.

We now have two projects underway to reduce the frequency of toxicity in children with ALL, especially in malnourished children.

However, the higher frequency of toxicity and interventions after GC therapy were not reflected in any HRQOL difference between the treatment arms.

We assumed the frequency of toxicity (symptoms or laboratory) as 60%% in the 10-mg folic acid group, and estimated that it would halve to 30%% in the folic acid 30-mg group.

The age and sex of patients, treatment groups, clinical characteristics at randomization, maximum haematological toxicity grades attained during treatment and frequency of toxicity symptoms are shown in Tables 1 and 2. The presence of B symptoms was associated with disease stages 3 or 4, performance levels 2 4, elevated LDH and positive bone marrow assessments (Table 3).

Although for some areas little to no evidence was found, including (the frequency of) toxicity monitoring, the timing of folic acid, non-orthopaedic surgery and the effect of methotrexate on fertility and lactation, the majority of the recommendations is supported by evidence from RCT and high-quality cohort studies.

Although substantial progress has recently been made in this area using parametric approaches, the method that is widely used is based on treating small cohorts of patients at escalating doses until the frequency of toxicities seen at a dose exceeds a predefined tolerable toxicity rate.

The frequency of toxicities of World Health Organisation (WHO) grade 3 or more are summarized in Table 3-wrap>.

However, the frequency of toxicities in the unblinded arms reviewed by the IDMC was below the 'cutoff' for stopping the trial.

However, FOLFIRI appears to be better tolerated than IFL and is associated with a lower frequency of toxicities such as diarrhoea, myelosuppression, and sepsis (Benson and Goldberg, 2003; Alimonti et al, 2004; Hwang, 2004).

We used the Chi square test, Fisher's exact test, or Wilcoxon two-sample test to compare patient characteristics, response to PEM, and the frequency of toxicities, as appropriate.