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Similarly, a reduction in antidiabetic therapy could underestimate the effect of ranolazine to lower A1C and FPG; however, there were no significant differences in the frequency of reductions in hypoglycemic agents between placebo and ranolazine in any of the study populations.
Similar(59)
The investigators may be reducing evidence of adverse effect by giving mean levels of these parameters; the frequency of reduction in these parameters by, say, 25% or some other clinically relevant amount was not presented.
Despite the frequency of dose reductions [35% (81/231)] needed with vandetanib, only 12% (28/231) of patients discontinued treatment due to AEs [ 7].
We wondered if differences in toxicity profiles may lead to a greater frequency of dose reductions or discontinuation of treatment, thus affecting response rates between the two populations.
In addition, overall, there were neither significant differences in frequency of dose reductions (P=0.6) nor treatment delays (P=0.2) according to weight change.
(i) The addition of regorafenib to standard treatment with FOLFOX or FOLFIRI may have resulted in a higher frequency of dose reductions and interruptions, resulting in reduced dose intensity.
Hence, in future studies of targeted agents, it will be useful to not only report the frequency of dose reductions but also to report any dose re-escalations in the patient population under study.
A reduction in RP patient's medical and non-medical costs is expected with improved visual acuity as the result of a decrease in the frequency of falls, reduction in depression/anxiety and reduced need for home care.
In this study, we found frequent reduction of WWOX expression in IPMC, which was almost equivalent to the frequency of WWOX reduction in IDC (Nakayama et al, 2008).
(2) what is the frequency of double-reduction ?
It is noteworthy that the frequency of WT1 reduction in expression is similar to that of WT1 mutation.
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