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Furthermore, there were no significant differences in frequency of reactive TCL to hMBP peptide 84-98 in DR15-positive or DR15-negative MS patients.
In MS patients the frequency of reactive T-cell lines (TCL), tested for fine specificity against the immunodominant hMBP peptides 84-98 and 143-168, was increased for the hMBP 143-168 Peptide (P < 0.05) but not for the 84-98 peptide.
This argues that there is not simply a change of function of antigen-specific T cells, but also a reduction in the circulating frequency of reactive T cells.
Plasma samples reacting with no subunits or with the A and/or B subunit of Stx2 and/or Stx1 are shown in Fig. 2. When samples were tested against Stx1, a similar low frequency of reactive samples was observed in all clinical groups (Fig. 2A) (HUS = 5%, HUSrec = 14%, NHC = 8%; p = 0.55, Chi-square test).
The overall frequency of reactive plasma with at least one subunit of Stx2 in NHC group (67%) was significantly lower than the frequency in HUS (86%) and HUSrec (82%) clinical groups (Fig. 2B) when compared by the Chi square test (p<0.05).
Seasonal vaccine administration may enhance the frequency of reactive CD4 T cells, boosting the cross-subtype cellular immunity against avian influenza (H5N1).
Similar(51)
We assessed not only the frequencies of reactive lymphocytes (Fig. 1A) but the production of IFNγ as well (Fig. 1B).
When the frequencies of reactive cells were compared between persons of different ages, no differences were noticed either (Fig. 1C), indicating that there was no waning of immunological memory towards HBHA with age.
The results of the analyses indicated that the maximum frequency points of active input power are different from the maximum frequency points of efficiency and the zero-frequency points of reactive input power.
However, CD patients had a higher frequency of MAP reactive T cells than the UC patients and also a higher frequency of response to MAP compared to other bacterial antigens.
These patients usually had responses in one single line T-cell line while patients with active CD had responses in several T-cell lines suggesting a higher frequency of MAP reactive T cells in the latter group.
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