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The frequency of polymorphism within species has been reported to be limited to 11% [ 14].
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Together negative and background selection decrease the number of polymorphisms and the average derived allele frequencies of polymorphisms within and surrounding functional elements (fig. 1).
Recombinant SNPs also do not show increased frequencies of polymorphisms within windows above local nonrecombinant polymorphism levels, indicating that they are not inherently mutagenic or driving the polymorphism levels intrinsically (Wilcoxon sign-rank test, P = 0.92, see Materials and Methods).
In both cases the frequency of polymorphisms found within these heterozygous genomes, was 2.6 [ 17] and 4 [ 57] SNPs per kb, respectively.
Based on information obtained from the NCBI database, the frequency of this polymorphism within the Caucasian population was reported to be 1.4% for the DNMT3A SNP (G301C, rs34843713) on the basis of 74 samples, 1.4% for the DNMT3B SNP (G301A, rs35846833) on the basis of 74 samples and 1.5% for the DNMT3A SNP (G301A, rs34191084) on the basis of 68 samples (Table 3).
The frequency of polymorphism is 0.0098 per bp on average.
Similarity was tested by mean Euclidean distance within groups of related genera for total frequency in simple plus compound loci, repeat count in simple loci, and frequency of polymorphism in simple loci.
Polymorphic information content that represent the amount of polymorphism within a population was estimated based on Botstein et al. (1980).
We used patterns of polymorphism within each group to detect instances of selection causing departure from the neutral frequency spectrum.
Knowledge of polymorphism within the GPCR superfamily is of interest.
Patterns of polymorphism within FZF1, the adjacent gene, indicated no excess of synonymous or nonsynonymous polymorphism.
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