Mutational screening revealed a high frequency of mutations.
Both N-RAS and K-RAS can be mutated, with different studies showing different frequency of mutations in these genes.
Samuels, Y. et al. High frequency of mutations of the PIK3CA gene in human cancers.
High frequency of mutations of the PIK3CA gene in human cancers.
We hypothesise a higher frequency of mutations affecting smokers.
Frequency of mutations in the gene encoding the alpha subunit of rod cGMP-phosphodiesterase in autosomal recessive retinitis pigmentosa.
We find that the frequency of mutations exhibiting epistasis increases along the evolutionary pathway.
The elevated frequency of mutations in outer membrane protein genes suggests that the mutation burst facilitates rapid host adaptation of the bacteria.
Myc and Myc E2f1 transgenic mice have a relatively higher frequency of mutations in β-catenin (Catnb) and nuclear accumulation of β-catenin that are indicative of lower genomic instability and better prognosis in human HCC26.
Moreover, a decrease of Lamin B1 has been associated with a release of chromatin from LADs and increased frequency of mutations in specific lymphocytes populations, with consequences in lymphomagenesis29.
Since JAK1, JAK2, and IFNGR1 were recently implicated as drivers of acquired or primary resistance to anti-PD1 and anti-CTLA4 therapies, respectively11, 12, we looked at the frequency of mutations and LOH in these genes within our cohort.
