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PRAF primarily focuses on early detection of unsafe domains of operation, assessment of aggregate risks and prioritization of safety barriers during process upset situations and reduction in response time resulting in a reduced frequency of loss of containment events (LoC), reduced consequences and enhanced recovery.
The second site also provides redundancy and reduces the frequency of loss of binding due to a mutation in one of the PAM2 sites.
The frequency of loss of OCT1 activity correlated with the frequency of loss of OATP1B1 activity (r = 0.531, P <10−4, Fig. 7d).
We observed strong inter-regional variations in the frequency of loss of OCT1 activity.
Worldwide, we observed strong variations in the frequency of loss of OCT1 activity (Fig. 6).
A similar frequency of loss of O -methylguanine-DNA methyltransferase expression was confirmed in these cases.
Our study could also confirm the high frequency of loss of PTEN expression among NSCLC cases.
Striking differences were observed in the frequency of loss of OCT1 activity worldwide.
The frequency of loss of heterozygosity in cases of usual hyperplasia is much lower.
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Using endogenous promoters in stead of the 35S CaMV resulted in a dramatic reduction in the frequency of loss-of-function phenotypes.
The highly variable frequency of loss-of-function OCT1 polymorphisms suggests the existence of selection pressure for losing (or maintaining) OCT1 activity in some world regions.
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