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We studied the relative frequency of grades of adduction deficit and the relative frequency of abnormal anatomic findings.
The frequency of grades 3 and 4 diarrhoea was the primary variable.
Additionally, the safety profile was in a favorable range, with a frequency of grades 3-4 irAEs of 5%[26]].
There was statistical difference in the frequency of grades 1 and 2 endometrioid adenocarcinoma between Groups I and II (52/53 vs. 56/78, P = 0.00026).
In a retrospective analysis of a randomised study evaluating a biweekly bolus irinotecan/5-FU/LV regimen, patients aged ⩾70 (n=17) did not suffer higher frequency of grades 3 4 toxicity compared to those aged under 70 (n=101) (Comella et al, 2003).
A higher frequency of grades 3 4 neutropenia in Japanese patients than in American patients was associated with combinations of cisplatin and irinotecan (65 vs 32%, P<0.001) and cisplatin and etoposide (92 vs 66%, P<0.001) for the treatment of extensive small-cell lung cancer (Lara et al, 2007).
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High frequency of grade crossings and difficulty of their elimination cause operational and safety challenges for increased train speeds in the U.S. [19].
These esophageal complications range from esophagitis to esophagus ulcer resulting in stricture, perforation, and/or tracheo-esophageal fistula, and the frequency of grade 1 2 and over grade 3 toxicity according to the Common Terminology Criteria for Adverse Events has been reported as up to 12.8% and up to 6.8%, respectively [5].
In the Radiation Therapy Oncology Group 98-01 trinl inon-smallll cell lung cancer patients receiving chemoradiation therapy, amifostine given intravenously four times weekly did not significantly reduce the frequency of grade 3 or 4 esophagitis; however, a significant reduction in severity over time was observed in patient swallowing diaries.
Although Grade 3 pain occurred with a low incidence, there was a trend towards a higher frequency of Grade 3 pain in the RTS,S/AS02D compared to the RTS,S/AS01E group (Figure 2).
Neuropathy has been a prominent side effect in previous phase II and phase III trials with a frequency of grade 3 neuropathy in the 5 20% range [14], [15], [16], [22], [23], [24].
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