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Holt et al. [14] identified fusion-gene generating CNVs in probands with ASD, however there was no difference in overall frequency of fusion transcripts between patients and normal controls.
If cell fusion plays a physiologically significant role in Purkinje cell development and/or survival, could the frequency of fusion be modified experimentally?
In mice, the frequency of fusion events does increase with time, suggesting fusion results in the formation of stable reprogrammed heterokaryons [ 23, 45, 46].
It was found that the frequency of fusion between MSCs and differentiated cells increased in the presence of TNF-alpha and/or IFN-gamma [ 67].
It is tempting to speculate that understanding the mechanisms underlying cell fusion may lead to techniques to increase the frequency of fusion events and to deliver 'healthy donor' cells and/or genes to degenerating neuronal cells.
In addition, the prediction of a higher involvement of the rDNA-bearing chromosomes in the Rb fusions was not confirmed in the house mouse, as a statistical analysis indicated that they had the lowest frequency of fusion [ 65].
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For the shortest 1/3, the frequency of fusions is linearly related to style rank (shorter styles being ranked higher).
Other regions with higher frequency of fusions are on chromosomes 1, 4, 6 and 19.
Importantly, the cancer-predisposing C61G mutation in BRCA1, which abrogates its E3 ubiquitin ligase activity, and disrupts the BRCA1 RING domain and its interaction with BARD1 (Drost et al, 2011), did not significantly alter the frequency of fusions induced by TRF2 depletion.
The net direction of selection from fusion should depend on the net inclusive fitness effects and relative frequencies of fusion between clone mates and non-clonemates.
As a result, counts for the frequency of fission and fusion illusions were pooled across two stimulus types (fissions: 1F2B+1F3B, fusions: 2F1B+3F1B) rather than the three used in [17].
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