Sentence examples for frequency of expansion from inspiring English sources

We have shown that single-strand-specific exonucleases with opposite polarities of DNA degradation, RecJ and ExoI, limit the frequency of expansion events.

The frequency of expansion varied from 3.6%too 11.2% among all screened cases, and from 6.3% to 38.2% among cases with a positive family history.

The absolute frequency of expansion mutations in PMS2-deficient LCL1261 cells is similar to that measured in MSH3,MLH1-deficient HCT116 cells (Table 2).

Despite this destabilization, the CTG leading-strand repeat array in a rep mutant can be seen to be a useful starting point from which to study repeat array expansion in E. coli as a ratio of ∼2:1 of contraction to expansion and an elevated frequency of expansion provides a useful background to investigate mutants enhancing or reducing the frequency of expansion events.

To our surprise, deletion of either the gene encoding the single-strand-specific DNA exonucelase RecJ or the single-strand-specific DNA exonuclease ExoI caused an increase in the frequency of expansion events.

Similarly, in the HD gene, as CAG repeat number increases, there is a significant increase in the frequency of expansion mutations and the mean number of repeats added per expansion [ 34].

However, we found no statistically significant difference in frequency of expansions between patients and healthy controls.

Fisher's exact test was used to calculate difference in frequency of expansions between groups.

Expansions also occurred at similar levels in HeLa nuclear extract, and preventing DNA replication did not alter the frequency of expansions.

Thus the frequency of expansions was approximately 500-fold greater when (CTG 25 was in the lagging strand template than when (CAG 25 was in the lagging strand template [ 17].

We found no significant difference in the frequency of expansions between sarcoidosis patients and controls in CD4+ cells (BAL p =0.17; PBMC p = 0.95).