Sentence examples for frequency of driver from inspiring English sources
While the identity and frequency of driver alterations are generally different in basal and luminal cancers, there is still considerable overlap.
His group found different epidermal growth factor receptor (EGFR) mutation rates in Caucasian and Chinese populations and also tested the frequency of driver genes in subgroups of NSCLC in Chinese.
16 Although the underlying alteration leading to such aberrant expression of pluripotency-related genes is not clear in medulloblastoma, the very low frequency of driver mutations in these tumors 17 and the recent association of differential DNA methylation status with LIN28B misexpression 18 indicate the contribution of chromosomal and epigenetic aberrations.
The studies assessed engineering-based behavioral interventions to increase the frequency of drivers' seat belt use.
Although fitness of a clone is not directly measurable, the growth rate of mutation frequency of drivers in this clone can serve as an indicator.
Similar outcomes also emerged from another study [ 33] that found a relationship between the number of prescriptions for BDZs in different Norwegian provinces and the frequency of drivers testing positive for BDZs from the same region.
Differences regarding the sequencing strategies and the tissue preservation methods (frozen or formalin-fixed paraffin-embedded material) may explain some discrepancies between the reported frequencies of driver mutations.
However, the objective of this study was not only to assess the frequencies of driver gene mutations, but also to assign patients to appropriate therapies and/or enrollment in clinical trials.
We therefore suggest that the frequency distribution of driver mutations and the distribution of resistant subclones within a heterogeneous cancer cell population could be used to instruct decisions of the time course of treatment levels, with the aims of curbing tumour growth, metastasis, and resistance.
Notably, in CRCs with EDMs, the spectrum and/or frequency of known driver mutations is unusual.
This difference may just be due to the low mutational frequency of many driver genes (e.g. NF1A, EED) [ 102] and to our current ignorance of other targets.
