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It is possible that our study suffered from a similar bias, overestimating the true β-hCG clearance time as once a declining β-hCG is established, the frequency of determinations decreased meaning that the true time of clearance is missed.
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This study has shown that the frequency of determination of the cortisol concentration is crucial because even a several-day interval in the assays can make that impact of the therapy on the cortisol secretion and the amplitude of the hormone level could not be noticed.
Other profitable features, such as a linear relationship between 0.50 and 10.0 g l−1 tartaric acid (r = 0.9998), a 2.1% coefficient of variation (n = 8), a sampling frequency of 28 determinations per hour, and a reagent consumption of 0.15 mg sodium vanadate per determination were also achieved.
The proposed method attained an analytical frequency of 36 determinations per hour with a relative standard deviation of 1.47% for 10 measurements of 1.0 × 10−5 mol L−1 CO.
A detection limit of 7.6 × 10−8 mol L−1 and a sampling frequency of 50 determinations per hour were achieved, employing injected volumes of 100 μL and a flow rate of 2.0 mL min−1.
Application of the monitoring rules, illustrated in Figure 4, shows that the frequency of CD4 determinations can be kept low while high counts are observed.
Moreover, a different frequency in measuring LFTs, which resulted in more frequent monitoring among naïve patients taking PI-based regimens, may have led to an increased detection of toxicity in that group, although a statistically significant correlation between the frequency of LFT determinations and the risk of hepatotoxicity was not present (data not shown).
In this regard, we can view (R_{xx}^{2}(lambda )) as a frequency-by-frequency coefficient of determination.
The method and frequency of glucose determination has a significant impact on variability measures as already shown with mean absolute glucose change per hour [ 27].
Determination of methylation frequency and correlation with clinicopathological parameters was performed using the MethyLight assay on DNA extracted from FFPE tissues.
The optimal threshold of HIV-RNA and the optimal frequency of HIV-RNA determination that best inform antiretroviral switches in RLS are still being debated.
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