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Exact(1)
The frequency of breakthrough medication use remained stable throughout both phases in the morphine group (52.5% in the IR phase, 48.8% in the SR phase), but decreased from the IR phase to the SR phase in the OROS® hydromorphone group (from 61.6% to 48.1%).
Similar(58)
Tuchman (2008), using zolmitriptan 2.5 mg BID and TID reported that both zolmitriptan regimens demonstrated superior efficacy vs placebo, as measured by ≥50% reduction in the frequency of MM and the mean number of breakthrough MM per menstrual cycle.
Dose adjustments, to be made after 2 days of therapy at a dose level, were then made as needed, based on the patient's degree of opioid tolerance, general condition and medical status, concurrent medication, type and severity of pain, and the amount and frequency of rescue medication needed for breakthrough pain.
This study assumed that HCV variants sampled at the time of breakthrough represent drug-resistant quasispecies, and if present at baseline, they must be present very low frequency.
However, studies on identification of breakthrough locations are infrequent.
The rates of breakthrough infection were comparable.
Methodological supervision of Breakthrough Lab's experimental work: PM.
A significant number of breakthrough infections were observed.
A considerable number of breakthrough infections was observed.
Statistical distributions of breakthrough forces were fit with Gaussian functions.
Conclusions: Penicillin remains the mainstay of prophylaxis, although breakthroughs occur and will become more common with the increasing frequency of penicillin-resistant organisms.
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