Sentence examples for frequency of alterations from inspiring English sources
Although several cancer-related genes are altered in HCC, the frequency of alterations for each individual gene is relatively low.
In order to evaluate the expression of MLK4 in breast cancer patients we analyzed 818 samples available in TCGA, which showed gene amplification and mRNA upregulation of MLK4 (MAP3K21) in invasive breast carcinoma at a frequency of 23%, in contrast to lower frequency of alterations (6 7%) in the rest of the MLK family members (Fig. 1a and Supplementary Fig. 1a) [1a,1a,1a].
While the frequency of alterations in cGAS and STING in tumours other than colorectal and melanoma remains to be ascertained, transcriptional repression by promoter hypermethylation is usually observed34,36, suggesting the therapeutic potential for demethylating agents to rescue responsiveness to radiation and immune checkpoint inhibitors.
Further, it is now commonplace to have a separate clause which legislates for how and when such white list can be altered – specifying whether the borrower can remove names from the white list and, if so, the circumstances and frequency of alterations.
Alterations affecting tumor suppressors and oncogenes, such as PTEN, MYC, BRCA2, and TP53, which have been long associated with aggressive PCa, demonstrated grade-dependent frequency of alterations in localized PCas.
Fewer alterations were found in patients with metaplasia alone and there was a significant trend towards a higher frequency of alterations with increasing histologic grade (p = 0.009).
Addressing the functions of these novel altered genes, given their frequency of alteration in gastric cancer, will probably be an important goal of future research work.
Frequency of alteration at each clone on the array was then calculated.
The phosphatidylinositol 3-kinase (PI3K) pathway has been the focus of intense pre-clinical and clinical investigation due to its high frequency of alteration in human cancers.
