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Dental caries represents a public health problem due to its high frequency in population and the cost it represents for society.
In addition, a candidate variant responsible for a rare disease should be found at a low frequency in population controls, consistent with the proposed model of inheritance and disease prevalence.
Finding variants in large numbers of people who are unaffected, as reflected in a high allele frequency in population studies, for example, is a powerful method for reclassifying variants as unlikely to be deleterious [ 32].
In population i the expected genotype frequency of genotype k after migration is g k, i ′ = (1 − m ) g k, i + m g k, j, where g k, i is the frequency of the k t h genotype in population i and g k, j is the k t h genotype frequency in population j.
Although the product of population size by isolation (captured in genetic models by the migration rate) is considered determinant for the spatial variance in gene frequency in population genetics theory, only a few empirical studies of wild populations have explicitly evaluated this interactive effect.
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The new advantageous allele relative to its ancestral allele exhibits higher frequency in populations under positive selection.
To be successful, most population replacement strategies for vector-borne disease control require introduced transgenes to spread to high frequency in populations [14] [15].
The observed multiple-resistance coupled with the occurrence of high kdr frequency in populations of An. arabiensis could profoundly affect the malaria vector control programme in Ethiopia.
Therefore, most likely purifying selection is responsible, with numerous slightly deleterious substitutions present at low frequency in populations, but which are prevented from going to fixation.
This model predicts that most elements are deleterious and segregate at low frequency in populations.
A small effect size might be sufficient to maintain the allele at low frequency in populations.
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CEO of Professional Science Editing for Scientists @ prosciediting.com