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This point of view is further supported by a study with a local anaesthetic (Ropivacaine) injection into these trigger points, which effectively reduced migraine frequency in approximately 60% of the participants in a non-controlled design including 52 chronic migraine patients [7] and another one which suggested beneficial effects of local therapy of active myofascial trigger points [8].
PB seems to be effective in decreasing seizure frequency in approximately 60−93 % of dogs with idiopathic epilepsy when plasma concentrations are maintained within the therapeutic range of 25−35 mg/l [ 10, 31, 74, 105].
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Age-adjusted score statistics provided support for these protective haplotypes in the case-control dataset (P1 frequency in cases approximately 13%, in controls approximately 20%, P = 0.001; P2 frequency in cases approximately 5%, in controls approximately 8%, P = 0.077).
In ROH tumours only, IGF2 LOI frequency occurred in approximately 56% of cases (14/25).
In the region of the auditory core areas, the modulation gradients cross the well-established frequency gradients in approximately perpendicular direction leading to an orthogonal representation of the temporal and spectral dimensions of sound.
A mutation in an immune system gene rapidly rose in frequency in Southeast Asia approximately 50,000 years ago because it likely conferred protection against leprosy, which spread to the region from Africa around the same time.
Overall, chromothripsis was detected at a substantial frequency in CLL (approximately 2%) through inference from SNP-array data, and was seen almost exclusively in CLL with IGHV-unmutated status and with mutated TP53.
More moderate fitness costs (≤5% per insert) can result in transgene frequencies approaching fixation in approximately 20 generations (Figure 4).
Assuming linear scaling future studies with ∼50 million markers from genome sequencing in 10 10 samples and even low (1%) allele frequencies can result in approximately >85 850 days of analysis.
The disorder has been most frequently reported in Japanese and Korean populations; its estimated frequency in Japan is approximately 2 in 100,000.
IDH1/2 mutational frequency in MPNs is approximately 0.8%, 1.9%, and 4.2% for ET, PV, and PMF, respectively (Tefferi et al. 2010).
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