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The low frequency identified in gastric mucosa of the younger patients may be because the stomach is not the primary location for B lymphocytes immortalized by EBV infection.
PAX5 was methylated in 77% of the HNSCC cases in the validation cohort, a number very similar to the 70% methylation frequency identified in the discovery set.
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Frequencies identified in patients with cancer were predominantly found above 1,000 Hz.
Studies are underway to dissect the biophysical mechanism leading cancer cells to respond to specific modulation frequencies identified in patients with a corresponding diagnosis of cancer but not to randomly selected or tumor-specific frequencies identified in other tumor types.
For example, 85% of the frequencies identified in patients with HCC were only found in other patients with HCC.
The 27.12 MHz signal was amplitude-modulated at the specific frequencies identified in patients diagnosed with cancer.
In general, frequencies of allelic loss reported in the literature are lower than the frequencies identified in our cohort of breast cancer samples.
The frequency of these mutations also did not differ from the frequencies identified in previously published Danish Caucasian control populations [ 10, 11].
Interestingly, the majority of frequencies identified in a given tumor type was only found in patients with the same tumor type [20].
Similarly, 75% of the frequencies identified in patients with breast cancer were only found in patients with the same tumor type [20].
When compared to mutation frequencies identified in three other large-scale sequencing studies [ 13– 15], we detected a greater mutational burden across all genes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com