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To gain deeper quantitative insights into GWAS transferability, we developed a complex trait coalescent-based simulation framework considering effects of polygenicity, causal allele frequency divergence, and heritability.
The allelic frequency divergence between POP1 and POP2 was 0.194, between POP1 and POP3 it was 0.120 and between POP2 and POP3 it was 0.197.
These analyses returned no evidence of significant allele frequency divergence at any value of K within the control and experimental groups when considered singly or as a whole.
Outlier loci with the most pronounced, replicable allele frequency divergence among selection treatments.
The original model is designed to model population divergence, and hence F is specified through Fst values (a measurement of allele frequency divergence) between different populations.
Selected SNPs and linked polymorphisms will likely exhibit greater allele frequency divergence and inflate the tails of the overall distribution of differences.
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Hence, in [19], the time and frequency divergences of the non-WSSUS vehicular channel at 5.2 GHz were characterized using spectral divergence measure.
The analysis of read counts for known miRNA families suggested the great expression frequency divergences among these miRNAs.
Significant frequency divergences occur on chromosome 13 in a region containing several cytochrome P450 (CYP) 3A genes.
Most existing methods for detecting and reconstructing historical admixture events are based on allele frequency divergences or patterns of ancestry segments in chromosomes of admixed individuals.
Importantly, our final expression for E[ z x, y)] still factors as the product of a d-dependent term now an exponential decay plus a constant and the allele frequency divergences δ(x) δ y).
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