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Exact(6)
Interestingly, with the 60 bp substrates srs2Δ displayed a synergistic interaction with both rad1Δ and rad59Δ as translocation frequencies were reduced 680-fold in the srs2Δ/srs2Δ radoubled1Δ double homozygote and 567-fold in the srs2Δ/srs2Δ rad59Δ/rad59Δ double homozygote, well below the frequencies observed in any of the single homozygotes (Figures 2 and 3).
Overall, spontaneous recombination frequencies were reduced by 94% in a strain lacking csk1+ compared to a wild-type strain (0.39±0.41 for csk1Δ vs. 6.1±1.9 for wild type) and the percentage of conversion types was also reduced (23% of total HR events for csk1Δ compared to 39% for wild type) (Fig. 4B).
When double-stranded templates 6 and 7 were used, HDR frequencies were reduced to 7%.
However, the positive control group presented elevated MNE and MNPCE frequencies (P < 0.0001), whereas the PCE frequencies were reduced (P < 0.007) (Table 1).
Fusion frequencies were reduced to 41.6% in PARP1-depleted MEFs and to 36.3% when BRCA1 was additionally deleted (Fig 4D and E), suggesting that PARP1 and BRCA1 are epistatic to each other with respect to telomere fusion formation.
By downmodulating Bmi1 in primary AML CD34+ cells, they found that progenitor and stem cell frequencies were reduced, and this was associated with increased expression of p14ARF and p16INK4A as well as an enriched level of intracellular reactive oxygen species.
Similar(54)
But Dr. Winfree cut through the detail, showing that, as the differences in the cells' frequencies are reduced, they abruptly fall into lockstep.
On the contrary, the fundamental frequencies is reduced in the present analysis.
With increasing PP or oil content in the blend the value of the modulus at low frequencies are reduced.
Regardless of the structural complexity, the problem of calculating the natural frequencies is reduced to that of solving two simultaneous non-linear algebraic equations.
In the absence of any one of the zmm genes, crossover frequencies are reduced, but not abolished [16].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com