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We calculated the power to detect the specified ORs at various allele frequencies of variant allele in additive models.
† Information about SNPs, SNP ID and frequencies of variant alleles in other ethnic populations were obtained from NCBI database.
The frequencies of variant CT and CC genotypes in our cases were similar to those in the prior studies [ 33, 35].
Smoking status contributed to the heterogeneity in hOGG1 Sestimatesesincethe, since the frequencies of variant alleles altered with different smoking behaviors [ 17, 21, 23, 31].
Hence, although most of the homozygous SNPs can be accurately identified in WGA samples, it is essential to investigate the allele frequencies of variant sites in order to not miss calls that were otherwise heterozygous in the sample.
However, performing such comprehensive analyses must take into account the relevance of certain polymorphisms for the clinical setting, for example very low frequencies of variant genotypes (e.g. dihydropyrimidine dehydrogenase (DPD) polymorphism).
Similar(52)
The gene frequencies of variants in the MBL gene in the Danish population studied correspond to previous reports on Caucasian populations.
Thus, the frequencies of variants in different genes vary remarkably in different populations.
Population databases (Table 1) are useful in obtaining the frequencies of variants in large populations.
Fig. S4 Frequencies of variants identified as private to the low-grade focus.
Of the 9 SNPs included initially, 3 SNPs (rs11465770, rs11465804 and rs11209026) were also excluded, because of their frequencies of variants of < 5 % in the controls.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com