However, the frequencies of developing metastasis only confined to distant LN, peritoneum or other organs were not significantly different between patients with WT and MT KRAS (Table 6).
Accordingly, our results indicate that upon PolyU or CpG stimulation, the frequencies of developing CD56+CD11c− immature NK cells significantly diminished, and a discrete CD56+CD11c+ mature NK cell population began to emerge from B-ALL or C-ALL precursors in 30-day cultures).
Estimation results show that the sibling spillover effect is large as a one-standard-deviation increase in one sibling's frequency of developing a stomach ache or a loss of appetite increases the other sibling's frequency of having the same symptom by about 55% of a standard deviation.
Logistic regression modelling was used to compare different groups in the frequency of developing TCE.
In the present long-term study, we found the frequency of developing abdominal obesity was highest among black women.
The frequency of developing AD in the offspring was significantly reduced by 2, 4, and 7 years, by 50%, 44%, and 36%, respectively.
For nephrotoxicity, ototoxicity and PNS toxicity, the relative frequency of developing toxicity was increased with higher exposure, most pronounced for renal toxicity.
Specifically there was a statistically significant decrease in the frequency of developing shortness of breath during physical activities (p = 0.008), in the appearance of cough (p = 0.002) and phlegm (p = 0.008) as also among daily activities at home (p = 0.034).
Nevertheless, we have observed that in severe atrophy of the thymus the number and frequency of developing extrathymic thymocytes bearing low TCR levels increase markedly during the acute phase [ 65].
For example, PARP-1 deficiency (deleting exon 2) in p53 null mice (Parp1 –/– p53 –/– ) enhances tumorigenesis as compared to Parp1 +/+ p53 –/– mice, resulting in a high frequency of developing mammary gland, lung, prostate, skin, and brain tumors.
An additional step that can increase the frequency of developing hybrids with the desired phenotype is a phenotypic prescreening of the self-mated homozygous diploids formed after sporulation and tetrad dissection of the homothallic parental strains (Romano et al., 1985; Marullo et al., 2009), or use of a well-designed backcrossing scheme (Marullo et al., 2009).
