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In the active, open conformation, these intramolecular interactions are weakened and the regulatory domains are freed to interact with other binding partners in the cell.
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These interactions do not involve PDZ domains, which are free to interact with additional protein partners 24.
These extended proteins are now free to interact with the colloidal tip causing an increase in the interaction energy and hence its friction.
For example, it is possible that the exofacial thiol targets of parthenolide are reduced on cancer cells, and thus are free to interact with the drug, but are oxidized on normal cells, thus unavailable for interaction with parthenolide.
How the PRH TLE interaction is regulated in cells and under what circumstances PRH is free to interact with other partners, including activators and co-activators, is yet to be explored and research in these areas will throw light on context-dependent functions.
Free to interact with humanity again.
Rather, God created a universe full of cosmic whatchmajiggers and subatomic whosits free to interact.
And feel free to interact with one another as you see fit.
Free RANKL expresses as a soluble unbound fraction, which is free to interact with its receptors (RANK, OPG).
In the absence of ligand, peptides expressed as fusions in an FKBP-peptide-FRB-GST LiRP scaffold protein are free to interact with target proteins.
The simplified model problem includes a steady base jet flow, maintained in the absence of disturbances, superimposed with instability waves that are free to interact nonlinearly.
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