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The skin has both free nerve endings and so-called corpuscular endings, which include nonnervous elements.
There are no specialized sensory receptors for itching in the skin; both itching and pain are transduced by free nerve endings located at the dermo-epidermal junction.
Free nerve endings occur in the epidermis, in the superficial dermis, where they are arranged in tufts, and in hair follicles.
There are six types of touch receptors in human skin, including free nerve endings, hair follicle receptors, Meissner corpuscles, Merkel endings, Ruffini endings, and Pacinian corpuscles.
Rugae accommodate various types of intraepithelial sensory structures such as Merckel cells and free nerve endings.
Laser-generated radiant heat pulses selectively excite free nerve endings in the superficial skin layers and activate Aδ and C nociceptors and evoke scalp potentials.
CGRP is also found in free nerve endings in skin and synovium) and perivascular afferents in different structures in both humans and animals [99 101].
We investigated the clinical efficacy of free nerve grafts in bridging gaps between the recurrent laryngeal nerve (RLN) and ansa cervicalis in patients with unilateral RLN injury.
TRPs are associated with free nerve endings of dorsal root ganglion neurons [9].
The intraepithelial fibers are generally considered to be free nerve endings [30], [42].
These fibers are generally believed to be free nerve endings reacting directly with chemical stimuli [30].
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