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This study indicates that metal-free click chemistry is effective to produce injectable dextran hydrogels for cartilage tissue engineering.
Using Cu-free click reaction, we successfully synthesized G-quadruplex-hemin conjugate that exhibited promising peroxidase activity.
This strain-promoted azide-alkyne cycloaddition is often referred to as "Cu-free click chemistry".
SA-N3 was polymerized with dibenzylcyclooctyne-modified branched poly ethyleneglycol) (DBCO-PEG) using azido-modified branched PEG (N3-PEG) as a spacer via copper-free click chemistry.
For the metal-free click reaction, chitosan and hyaluronan were modified with oxanorbornadiene (OB) and 11-azido-3,6,9-trioxaundecan-1-amine (AA), respectively.
