The majority of methods of the conversion of fatty materials (including rapeseed oil) to fuel components is fraught with side formation of glycerol, according to the scheme: triglyceride + alcohol → fatty acid ester + glycerol (3).
Since treatment is prolonged, expensive and fraught with side effects, intense efforts have been made to identify biomarkers predictive of a successful treatment outcome.
Chelating therapy with DFO in dialysis patients is fraught with side-effects and hence iron and aluminium overload should be prevented in this population.
In addition, currently available therapies are fraught with numerous side effects, often causing significant life-long morbidity for long-term survivors.
But this paradigm overlooks the inherent complexity of human diseases and has often led to treatments that are inadequate or fraught with adverse side effects.
What she doesn't say — because she hasn't consulted the research — is that most studies find the treatment ineffective and fraught with negative side effects.
However, such an intervention may also be fraught with significant side effects in small infants, and its systematic application is controversial.
It has been quite fraught on both sides.
The final stages were fraught for the Parkhead side, with every ball into their box fraying further the nerves of their fans, but Aberdeen ran out of steam, leaving Celtic to celebrate a victory, and a title win, that should have been so much easier.
The performance against Uruguay, although it resulted in a win, was fraught, one of a side battling with their own awareness of history – and also with the ever knotty issue of Carlos Tevez, whose popularity, political clout and tendency to sulk mean his omission from the starting lineup always creates tension.
