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Indeed, Stephenson's own predicament in the midst of such a towering project is succinctly encapsulated in one character's fraught observation: "Why did I study Linguistics instead of Celestial Mechanics?
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But science does not rest solely on observation no matter how intense and fraught with implications those observations may be.
This methodology is fraught with limitations as it provides one time observation and includes tissue damage, toxicity, laborious technical procedures, as well as tangential assessment of disease pathophysiology.
This is difficult to assess experimentally, as same-heart observations of histo-anatomical detail in more than one deformation state are fraught with technical challenges (one cannot do histology on the same heart twice, and diffusion tensor MRI has limited resolution).
Moreover, observation of polyps detected in annual colonoscopies until they grow into cancer would be fraught with ethical problems.
They get more fraught.
The balloting was fraught.
It's fraught".
Their friendship was fraught.
Elections are fraught.
Those were fraught days.
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CEO of Professional Science Editing for Scientists @ prosciediting.com