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Insulin resistance is a common consequence of obesity, and is frequently a prelude to frank type 2 diabetes [ 1].
The prediabetic period, which can last for decades, is characterized by metabolic modifications which eventually lead to frank type 2 diabetes.
In adults, prediabetes precedes frank type 2 diabetes by 5 10 years (6, 7); however, similar data are limited in younger populations.
Weiss et al. (8) have noted that obese youth with IGT decompensate to frank type 2 diabetes over a mean follow-up of 20 months.
Thus, postprandial hyperglycemia may represent a key factor in the progression from impaired glucose tolerance (IGT) toward frank type 2 diabetes and cardiovascular disease in older people (1).
In 1987, Pories et al. (1) published a stunning observation that 99% of morbidly obese patients with frank type 2 diabetes or impaired glucose tolerance who had undergone Roux-en-Y gastric bypass (RYGB) became and remained euglycemic after surgery.
Similar(53)
Transmission electron microscopy has revealed that the displacement vector of the accompanying SF is in the {0 0 0 1} basal plane, whereas the interface between the 3C inclusion and 4H matrix is composed of Shockley-type and Frank-type partials.
Unlike dislocation generation by Frank-Read type sources, this process is a thermally driven, stress-assisted cooperative instability of many dislocation loops (dipoles in two dimensions).
To depict the three stages of material characteristics such as linear elasticity, a plateau with stress drop, and densification under uniaxial compression numerically, a Frank-Brockman type plastic multiplier and a Zairi type hardening-softening internal stress state variable were introduced.
Frank is frank.
That is, most types of physicians tend to avoid frank disclosure for most types of patients with cancer".
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CEO of Professional Science Editing for Scientists @ prosciediting.com